|
Testicular Immunology is the study of the immune system within the testis. It includes an investigation of the effects of infection, inflammation and immune factors on testicular function. Two unique characteristics of testicular immunology are evident: (1) the testis is described as an immunologically privileged site, where suppression of immune responses occurs; and, (2) some factors which normally lead to inflammation are present at high levels in the testis, where they regulate the development of sperm instead of promoting inflammation. == History of testicular immunology == * 460-377 BC Hippocrates described testicular inflammation associated with mumps * 1785 Hunter and Michaelis performed transplant experiments in domestic chickens * 1849 Berthold transplanted testes between roosters and showed maintenance of male sex characteristics only in birds with successfully grafted testes 〔 * 1899-1900 Sperm recognized as immunogenic (will cause an autoimmune reaction if transplanted from the testis into a different area of the body) by Lansteiner (1899) and Metchinikoff, (1900)〔 * 1913-1914 Human testis transplants performed by Lespinasse (1913), and Lydson (1914) who performed a graft on himself! 〔 * 1954 Discovery that sperm autoantibodies contribute to infertility, * 1977 Billingham recognized that the testis is site of immune privilege 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Testicular immunology」の詳細全文を読む スポンサード リンク
|